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Glandular fever, also known as infectious mononucleosis, is a viral illness caused primarily by the Epstein-Barr virus (EBV). It is commonly referred to as the “kissing disease” due to its transmission through saliva. While many recover within weeks, some individuals experience long-term fatigue, immune dysfunction, and chronic inflammation, leading to conditions such as post-viral syndrome and reactivated EBV.

A functional medicine approach focuses on supporting the immune system, reducing inflammation, optimizing mitochondrial function, and restoring gut health to promote full recovery and prevent long-term complications.

What Is Glandular Fever?

Glandular fever is a viral infection that primarily affects the lymphatic and immune systems. It is most common in adolescents and young adults but can affect individuals of all ages.

Symptoms of Glandular Fever

• Severe fatigue and weakness
• Swollen lymph nodes (neck, armpits, groin)
• Sore throat and tonsillitis
• Fever and chills
• Headaches and muscle aches
• Swollen spleen or liver inflammation

Most symptoms resolve within two to four weeks, but some individuals develop chronic EBV-related fatigue and immune dysregulation.

The Epstein-Barr Virus (EBV) and Chronic Fatigue

After an initial infection, EBV remains dormant in the body and can reactivate under stress, immune suppression, or chronic inflammation.

Reactivated EBV has been linked to:

• Chronic Fatigue Syndrome (CFS/ME)
• Autoimmune conditions (Hashimoto’s thyroiditis, multiple sclerosis, lupus)
• Long COVID and post-viral syndromes

Functional Medicine Strategies for Glandular Fever Recovery

1. Strengthening the Immune System

Since EBV weakens the immune system, optimizing immune function is essential.

Key nutrients for immune support:

• Vitamin C – Reduces viral load and supports white blood cell function.
• Zinc – Essential for immune modulation and antiviral defense.
• Vitamin D3 – Regulates immune response and reduces inflammation.

2. Reducing Inflammation and Oxidative Stress

Chronic EBV infections can lead to persistent inflammation and oxidative stress, contributing to fatigue, brain fog, and joint pain.

Key antioxidants for reducing inflammation:

• Glutathione and N-acetylcysteine (NAC) – Support detoxification and reduce viral replication.
• Curcumin and resveratrol – Anti-inflammatory compounds that support immune resilience.

3. Supporting Mitochondrial Function for Energy Production

Mitochondrial dysfunction is common in post-viral fatigue and EBV-related chronic conditions. Supporting ATP (cellular energy) production can improve recovery.

Mitochondrial support nutrients:

• CoQ10 and PQQ (Pyrroloquinoline quinone) – Enhance mitochondrial energy output.
• L-carnitine – Aids in fatty acid metabolism for energy.
• B vitamins (B1, B2, B3, B5, B6, B12) – Essential for mitochondrial function.

4. Optimizing Gut Health and Detoxification

Since 70% of the immune system resides in the gut, a healthy gut microbiome is crucial for long-term immune function and inflammation control.

Key strategies for gut healing:

• Probiotics (Lactobacillus and Bifidobacterium strains) – Restore microbial balance.
• L-glutamine and zinc carnosine – Repair intestinal lining and prevent leaky gut.
• Eliminating inflammatory foods (gluten, dairy, processed sugars) – Reduces immune overactivation.

5. Managing Stress and Restoring the Nervous System

Chronic stress weakens the immune system and increases EBV reactivation risk. Supporting adrenal function and nervous system regulation is key for long-term recovery.

Stress management techniques:

• Meditation and breathwork – Lowers cortisol and reduces inflammation.
• Adaptogenic herbs (ashwagandha, rhodiola, holy basil) – Modulate stress response.
• Gentle exercise (yoga, walking, tai chi) – Supports circulation and lymphatic drainage.

6. Sleep Optimization for Immune Repair

Quality sleep is essential for immune recovery and cellular repair. EBV can cause insomnia, disrupted circadian rhythms, and non-restorative sleep.

Strategies to improve sleep:

• Magnesium glycinate and L-theanine – Promote relaxation and deeper sleep.
• Blue light reduction at night – Supports melatonin production.
• Herbal teas (chamomile, valerian root, passionflower) – Enhance sleep quality.

Preventing EBV Reactivation and Chronic Fatigue

While most recover from glandular fever within weeks, some develop chronic EBV-related fatigue and immune dysfunction. Ongoing immune support, stress management, and gut healing can reduce the risk of reactivation.

Looking for Expert Guidance on Glandular Fever Recovery?

If you’re struggling with post-viral fatigue, chronic EBV symptoms, or immune dysfunction, here’s how I can help:

1. Learn More with My Online Program

For a comprehensive, step-by-step guide to optimizing health, my self-paced online program provides guidance on:

✅ How to use functional medicine to support immune function and prevent viral reactivation
✅ How to balance energy levels and improve mitochondrial health after EBV
✅ How to restore gut health and detox pathways for long-term wellness

🔗 Explore The Functional Medicine Solution to learn more.

2. Get Personalised Support with 1:1 Consultation Packages

📞 Learn More About My Consultation Packages for details on how we can work together.